Antioxidant probucol as an effective scavenger of lipid radicals in low density lipoproteinsin vivo andin vitro |
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| Authors: | A K Tikhaze B Z Lankin G G Konovalova K B Shumaev A I Kaminnyi A I Kozachenko S M Gurevich L G Nagler T M Zaitseva V V Kukharchuk |
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| Institution: | (1) Laboratory of Biochemistry of Free Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow |
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| Abstract: | Probucol in concentrations of 10–15 μM effectively inhibits Cu2+-induced free radical oxidation of native low density lipoproteins and in concentration of 100 μM it inhibits lipoperoxide
formation. The mean plasma concentration of probucol in patients receiving 250 mg of this drug is 25 μM. Both 250 and 1000
mg probucol daily during 3–6 month block the oxidation of isolated low density lipoproteins. Electron paramagnetic resonance
spectrometry data showed that probucol incorporatedin vivo into lipoprotein particles interacts with lipid radicals yielding long-lived phenoxyradicals. Probucol can be used in complex
therapy of atherosclerosis as an antioxidant drug and its dose required for lipoprotein protection against atherogenic modification
can be decreased to 250 mg/day.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 186–189, August, 1999 |
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| Keywords: | low density lipoproteins antioxidants probucol free radical oxidation lipoperoxides |
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