Serum 1,25-dihydroxyvitamin D concentrations in premature infants: Preliminary results |
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| Authors: | Dr. Laura S. Hillman Sharon Salmons Shigeharu Dokoh |
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| Affiliation: | (1) The Edward Mallinckrodt Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, 400 S. Kingshighway Blvd., P.O. Box 14871, 63178 St Louis, Missouri;(2) Division of Neonatology, St. Louis Children's Hospital, Washington University School of Medicine, 400 S. Kingshighway Blvd., P.O. Box 14871, 63178 St Louis, Missouri;(3) Department of Biochemistry, College of Medicine, University of Arizona, Tuscon, AZ |
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| Abstract: | Summary Serum 1,25(OH)2D concentrations were measured in serial serum samples from 19 premature infants of 29.6±1.3 weeks gestation and 1,129±159 g birthweight. 1,25(OH)2D was always normal or elevated and mean concentrations increased with age (adult, 55.2±13; infants, 1–2 weeks, 81.5±37.7 pg/mg; 3 weeks, 65±21; 6 weeks, 90.0±17.3; 9 weeks, 99.0±25.1; 12 weeks, 103.3±26.6 pg/ml). No correlation was seen with 25-OHD. Infants given 800 IU D2 supplements had lower 1,25(OH)2D levels than infants given 400 IU D2. Breast fed infants had initially higher 1,25(OH)2D levels; however, this was not sustained. These preliminary data suggest that premature infants regulate 1,25(OH)2D production similar to more mature infants and children. Whether the premature infant has a normal gastrointestinal and/or bone responsiveness to 1,25(OH)2D and whether these elevated 1,25(OH)2D concentrations are “adequately elevated” requires further study. NIH Grant 2R01HD-09998-06. |
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| Keywords: | 1,25-Dihydroxyvitamin D Premature infant |
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