采石工人血清脂质过氧化水平和抗氧化酶活性的研究

目的　探讨二氧化硅粉尘对人体作用中的脂质过氧化机制 ,寻求矽尘作业人员早期健康监测灵敏指标。方法　整群抽取 10 4名长期从事矽尘作业的采石工人和 10 1名无接尘、接毒史的健康工人为研究对象。分别测定血清中丙二醛 (MDA)、超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH Px)的含量并对其结果进行相应的统计分析。结果　接尘组血清MDA、SOD均高于对照组 ,而GSH Px则低于对照组 ,且均有统计学意义。 3项指标的异常检出率均高于对照组 ,其中MDA、SOD差异有显著性。接尘组MDA含量与SOD呈正相关 ,而与GSH Px呈负相关 ,3项指标均与累积接尘剂量有一定的相关。结论　二氧化硅粉尘可引起接触者体内脂质过氧化水平和抗氧化酶活性改变

Studies on serum level of lipid peroxidation and activity of anti-oxidase in Quarrymen

Objective To study the mechanism of the role that lipid peroxidation plays in the effects of silica dust on the human bodies and to find a sensitive indicator in early health monitoring for the exposed employees.Methods One hundred and four quarrymen exposed to silica dust for a long time and 101 non exposed healthy men were selected with cluster sampling.Serum levels of malondialdehyde(MDA),superoxide dismutase(SOD)and glutathion peroxidase(GSH Px) were determined for all the subjects,and the data were analyzed statistically.Results Serum levels of MDA and SOD were higher in the exposed group than those in the controls,but serum level of GSH Px was lower in the exposed group than that in the controls,with statistical significance.The rates of abnormal levels of serum MDA,SOD and GSH Px were higher in the exposed group than those in the controls,with statistical significance only for MDA and SOD.Serum level of MDA correlated with that of SOD and inversely with that of GSH Px in the exposed group.All the three indicators correlated with cumulative silica dust exposure to certain extent.Conclusion Silica dust could cause changes in serum level of lipid peroxidation and antioxidase activity in the bodies of those exposed.