急性冠状动脉综合征与血尿酸的相关性研究

目的探讨急性冠状动脉综合征(acute coronary syndrome,ACS)与血尿酸的关系及ACS患者血尿酸升高的相关危险因素。方法选择ACS患者306例,根据诊断分为急性心肌梗死(acute myocardial infarction,AMI)组150例,不稳定性心绞痛(unstable angina pectoris,UAP)组156例。又根据血尿酸水平分为:A组(血尿酸<260.0μmol/L)102例、B组(血尿酸260.0～356.9μmol/L)127例、C组(血尿酸>356.9μmol/L)77例,另选择健康体检者160例作为对照组。观察各组年龄、性别、吸烟史、饮酒史、高血压史、脂肪肝情况、LVEF、血肌酐、尿素、TG、TC、HDL-C、LDL-C、糖化血红蛋白,采用logistic回归分析血尿酸升高的主要因素。结果 AMI组和UAP组血尿酸水平明显高于对照组,差异有统计学意义(P<0.05)。A组、B组、C组在性别、脂肪肝、LVEF、血肌酐和TG等方面差异有统计学意义(P<0.05)。logistic回归分析显示,尿素、血肌酐、TG是ACS患者血尿酸升高的危险因素。结论 ACS患者具有较高的高尿酸发生率,且尿素、血尿酸、TG水平升高可能为ACS患者发生高尿酸血症的重要原因。

Correlation between acute coronary syndrome and hyperuricemia

Objective To sdtudy the correlation between acute coronary syndrome(ACS) and hyperuricemia and the risk factors for hyperuricemia in ACS patients.Methods Three hundred and six ACS patients were divided into acute myocardial infarction(AMI) group(n=150) and unstable angina pectoris(UAP) group(n=156).The patients were further divided into group A(n=102) with its uric acid(UA)<260.0 μmol/L),group B(n=127) with its UA being 260.0-356.9 μmol/L,and group C(n=77) with its UA >356.9 μmol/L.One hundred and sixty persons undergoing health check served as a control group.Their gender and age,history of smoking,drinking and hypertension were recorded.Fatty liver was detected.Their LVEF and serum levels of BUN,Cr,TC,TG,HDL-C,LDL-C and HbAlc were measured.Major risk factors for hyperuricemia were analyzed by multivariate logistic regression analysis.Results The serum UA level was significantly higher in AMI group and UAP group than in control group(P<0.05).The gender,fatty liver,LVEF,and serum levels of BUN,Cr and TG were significantly different in groups A-C(P<0.05).Multivariate logistic regression analysis showed that BUN,Cr and TG were the risk factors for hyperuricemia in ACS patients.Conclusion The incidence of hyperuricemia is rather high in ACS patients.Elevated levels of BUN,Cr and TG maybe an important reason for hyperuricemia in ACS patients.