Effect of phenobarbital on the activity of RNA polymerase II during diethylnitrosamine-induced hepatocarcinogenesis in the rat |
| |
| Authors: | H Kikuchi M Watanabe |
| |
| Affiliation: | 1. Department of Biochemistry and Molecular Biology, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030 USA;2. Department of Cancer Chemotherapy and Prevention Research Institute for Tuberculosis and Cancer, Tohoku University, 4-1 Seiryo-machi, Sendai 980 Japan |
| |
| Abstract: | The effects of dietary phenobarbital (PB) on RNA polymerase II (nucleoside triphosphate: RNA nucleotidyltransferase, EC 2. 7. 7. 6) in the liver of male Sprague-Dawley rats previously administered diethylnitrosamine (DENA) were studied. When a diet containing 0.05% phenobarbital was administered, the activity of DNA-dependent RNA polymerase II in the liver nuclei of rats was temporarily increased 1 and 2 weeks after the onset of feeding and expressed to be relatively higher afterwards, compared with the activity in rats fed the control diets. |
| |
| Keywords: | To whom reprint requests should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
