Effects of a High-sucrose Diet on Body Weight, Plasma Triglycerides, and Stress Tolerance |
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| Authors: | Masao Kanazawa MD PhD Chang Young Xue PhD Haruaki Kageyama PhD Eiji Suzuki MD PhD Rokuro Ito MD PhD Yoshio Namba MD PhD Toshimasa Osaka PhD Shuichi Kimura PhD Shuji Inoue MD PhD |
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| Affiliation: | Third Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.;Department of Geriatric Health and Nutrition, National Institute of Health and Nutrition, Tokyo, Japan.;Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.;Department of Psychiatry, Kitazato University.;Department of Food Science and Nutrition, Showa Women's University, Tokyo, Japan.;Department of Nutrition and Physiology, Kyoritsu Women's University, Tokyo, Japan. |
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| Abstract: | We examine the effects of feeding a high-sucrose diet on body weight gain, plasma triglycerides, and stress tolerance in rats. Feeding a high-sucrose (60%) diet for 2 weeks did not induce a greater body weight gain compared with that of standard diet when caloric intake was similar in ventromedial hypothalamic–lesioned obese and shamoperated lean animals. The high-sucrose diet elevated plasma triglycerides by increasing the triglyceride secretion rate and decreasing the fractional catabolic rate in both groups. In response to stress, feeding a high-sucrose diet for one week induced enhanced gene expressions of heat shock proteins (HSP 70 and 27) and suppressed NOx production in the brain, whereas the standard diet did not. Results suggest that feeding a high-sucrose diet does not induce obesity in lean rats or enhance weight gain in obese rats, if caloric intake is appropriate. The diet does elevate plasma triglycerides in lean and obese rats, but it may have the potential to improve stress tolerance. |
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| Keywords: | high-sucrose diet weight gain plasma triglycerides heat shock protein |
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