援生力维和小剂量抗抑郁药治疗难治性肠易激综合征的临床疗效

目的 观察援生力维和小剂量抗抑郁药治疗难治性肠易激综合征（IBS）的临床疗效。方法64例IBS患者，在谷雏素、维生素B1、维生素C等治疗基础上，治疗组加用援生力维200mg，3次／d，疗程4周。观察治疗前后患者腹痛、腹泻、便秘、腹胀的情况。结果治疗组4周末总有效率71．9％，8周末总有效率84、4％，均显著高于对照组（P＜0、01）；8周末腹痛缓解率86．7％，腹泻缓解率81．0％，便秘缓解率78、6％，腹胀缓解率81．3％，均明显高于对照组（P＜．05或0．01）。均无明显不良反应发生。结论援生力维和小剂量抗抑郁药治疗难治性IBS安全有效。

Clinical therapeutic effect of trimebutine and small dose of antidepressants on refractory irritable bowel syndrome

Objective To observe the clinical efficacy of trimebutine and small dose of antidepressants in the treatment of refractory irritable bowel syndrome (IBS).Methods 64 IBS patients took 200mg trimebutine,three times a day,for 4 weeks in addition to oryzanol,vitamin B_1 and vitamin C.The changes of abdominal pain,diarrhea,constipation and abdominal distension were observed before and after treatment.Results The total efficacy rate of treatment group was 71.9% at the end of fourth week and 84.4% at the end of eighth week which were higher than that of control group(P<0.01).At the end of eighth week,the remission rates of abdominal pain,diarrhea,constipation,and abdominal distension were 86.7%,81.0%,78.6,and 81.3%,respectively.There was no obvious adverse effect.Conclusion Trimebutine plus small dose of antidepressants is effective,which were significantly higher than in control group(P<0.05 or 0.01)and safe in the treatment of refractory irritable bowel syndrome.