Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis |
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Authors: | Dahm Anders E A Bezemer Irene D Bergrem Astrid Jacobsen Anne F Jacobsen Eva M Skretting Grethe Rosendaal Frits R Sandset Per Morten |
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Institution: | Department of Haematology, Oslo University Hospital Rikshospitalet, Oslo, Norway. |
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Abstract: | Venous thrombosis (VT) is one of the leading causes of maternal death in the western world, but the genetic causes of pregnancy-related VT are insufficiently understood. The aim of this study was to investigate the association between common genetic variations in candidate genes and pregnancy-related VT. We undertook a hospital based case-control study of women with VT during pregnancy or puerperium; controls were women giving birth without having VT. Single nucleotide polymorphisms (SNPs) were selected in 49 pre-specified candidate genes involved in coagulation, inflammation, and hormonal metabolism in 313 cases and 353 controls. We found new associations between SNPs and total pregnancy-related VT in the genes encoding coagulation factors V and VIII, and p-selectin. Additional new associations between SNPs and antenatal VT were found in the genes encoding the epidermal growth factor receptor, the pregnane X receptor, and protein S. Of 21 SNPs previously associated with thrombotic disease, rs2289252 in F11 and rs3917643 in F3 were associated with pregnancy-related VT, while rs4524 in F5 was associated with antenatal VT. |
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Keywords: | pregnancy venous thrombosis single nucleotide polymorphisms epidemiology |
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