尿毒清片对正常大鼠利尿及血瘀大鼠血液流变学的影响

目的 :观察尿毒清片对正常大鼠利尿及血瘀大鼠血液流变学的影响并与原剂型比较 ,为其临床应用和剂型改革提供实验依据。方法 :用代谢笼试验方法 ,观察尿毒清片对 1%生理盐水溶液负荷大鼠排尿的影响 ;采用LG R80全自动血液粘度测试仪测定血瘀大鼠模型全血、血浆的粘度变化 ;分离血浆 ,用比浊法测定纤维蛋白原含量。结果 :尿毒清片各剂量组对正常大鼠均具有利尿作用 ,但只有大、中剂量增加 6h内尿量具有统计学意义 ;清片各剂量组均可明显降低血瘀大鼠的全血粘度 ,降低血浆纤维蛋白原含量 ,作用强于尿毒清颗粒剂组。结论 :尿毒清片具有利尿 ,改善血瘀大鼠的血液流变学的作用 ,有利于延缓CRF的进程。

The Effect of Niaoduqing Tablet on the Diuresis in Normal Rats and the Hemorheology in Blood-stasis Rats

Objective: To observe the effect of the Niaoduqing Tablet(NDT) on the diuresis in normal rats and the hemorheology in rats of blood stasis and compare it with the Niaoduqing Granule(NDG) , so as to provide some laboratory data for the clinic application and innovation of the dosage forms. Method: Diuretic effect of the NDT on experimental rats burthened with 1% Sodium deoxycholate was observed by using the metabolize cage examination. The changes of whole blood and plasma viscosity in the blood stasis rat model were measured with Viscometer-R80. Plasma was separated and fibrinogen measured by using the turbidimetric method. Result:Every dose of NDT had the diuretic effect on experiment rats, but only the big and middle dose increasing the urine quantity in 6 hours had the significance. Each dose could reduce the viscosity of whole blood and the fibrinogen in the blood stasis rat model, and had the superiority to NDG. Conclutions:NDT has the diuretic effect and can ameliorate the hemorheology in the blood stasis rat model, which may delay the course of the chronic renal failure (CRF).