加味天雄散对弱精子症患者精浆氧化损伤的保护作用

目的 :观察加味天雄散对弱精子症患者精浆氧化损伤的影响并探讨其机制。方法 :本组120例随机分为对照组、加味天雄散全方组、补肾组和健脾组,每组30例,并设立精液分析正常的健康志愿者30例。4组分别治疗3个月后检测精液质量和精浆超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:治疗后全方组A级精子和A+B级精子百分率改善更明显(P0.01),与健康志愿者相比,弱精子症患者精浆SOD活力明显降低,精浆MDA水平明显下降,治疗后全方组患者精浆SOD活力提高更为明显,精浆MDA水平降低更为明显,差异有统计学意义。结论:加味天雄散能够提高精浆组织的抗氧化水平,降低精浆MDA水平,提高精子的活力。

Protective Effect of Jiawei Tianxiong Powder on Seminal Plasma Injury Induced by Oxidative Damage in Patients with Asthenospermia

Objective:To observe the effect and mechanism of Jiawei Tianxiong powder on seminal plasma injury induced by oxidative damage in patients with asthenospermia. Methods:There were 120 patients randomly divided into 4 groups:control group,Jiawei Tianxiong powder group,tonifying kidney group,tonifying spleen group,30 cases in each group. Besides there were 30 healthy volunteers with normal semen. Three months after treatment,semen quality and seminal plasma SOD and MDA levels were examined. Results:After the treatment,the percentage of grade A and grade A+ B sperm were improved obviously in the Jiawei Tianxiong group(P <0.01). Compared with the healthy volunteers,patients with asthnospermia showed obviously low seminal plasma SOD level and high seminal plasma MDA level. After the treatment,seminal plasma SOD level was increased and seminal plasma MDA level was decreased with significant statistical difference. Conclusion:Jiawei Tianxing powder can improve the antioxidant ability in seminal plasma,and reduce seminal plasma MDA level. Therefore it could enhance the sperm vitality.