甘酸缓急方对高血压肝阳上亢型肾素-血管紧张素-醛固酮系统的影响

目的 :观察甘酸缓急方治疗原发性高血压肝阳上亢型的临床疗效及其对肾素-血管紧张素-醛固酮系统(RAAS)活性的影响。方法:选取128例轻、中度高血压患者随机分为甘酸缓急方治疗组和西医治疗对照组,两组均予以氨氯地平口服,治疗组加用甘酸缓急方,治疗4周后,观察两组中医证候积分、诊室血压以及血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)水平的变化情况。结果:与治疗前相比,两组中医证候积分、诊室血压均明显改善(P0.05);与对照组相比,治疗组中医证候积分、诊室血压改善更加明显(P0.01),PRA、AngⅡ、ALD下降更加显著(P0.05)。结论:在西医治疗基础上加用甘酸缓急方能进一步抑制RAAS系统的活性,降低血压,改善临床症状。

Effect of Gansuan Huanji Formulas on the Renin-Angiotensin-Aldosterone System in Hypertension of Liver Yang Hyperactivity type

Objective:To observe the clinical effect of Gansuan Huanji formulas on the rennin-angiotensin-aldosterone system(RAAS) in the patients with hypertension of liver Qang hyperactivity type.Methods :There were 128 cases of patients with mild and moderate hypertension randomly divided into treatment group and the control group. Both groups were treated with amlodipine orally,while the treatment group was also given Gansuan Huanji formulas. After 4 weeks of treatment,in the two groups changes of traditional Chinese medicine(TCM) syndrome score,clinical blood pressure,plasma renin activity(PRA),angiotensin Ⅱ(Ang Ⅱ)and aldosterone(ALD) were observed. Result :After the treatment,TCM syndrome score and clinical blood pressure of two groups were significantly improved(P<0.05);in the treatment group,TCM symptom score and clinical blood pressure were changed more obviously than the control group(P<0.05),and PRA,Ang Ⅱ and ALD were reduced more significantly than the control group(P <0.05). Conclusion :The use of Gansuan Huanji formula in combination with western medicine can inhibit the activity of RAAS,reduce blood pressure and improve clinical symptoms.