| Bmi1在前列腺癌中的表达及临床意义 |
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| 引用本文： | Bmi在前列腺癌中的表达及临床意义. Bmi1在前列腺癌中的表达及临床意义[J]. 首都医科大学学报, 2016, 37(3): 323-326. DOI: 10.3969/j.issn.1006-7795.2016.03.013 |
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| 作者姓名： | Bmi在前列腺癌中的表达及临床意义 |
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| 作者单位： | 1. 首都医科大学附属北京安贞医院泌尿科, 北京 100029;2. 首都医科大学附属北京安贞医院病理科, 北京 100029;3. 首都医科大学2011级临床五年2班, 北京 100069;4. 首都医科大学2011级临床七年班, 北京 100069 |
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| 基金项目： | 北京市卫生系统高层次卫生技术人才基金(2013-2-003),2014年首都医科大学本科生科研创新课题(XSKY2014112)。 |
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| 摘 要： | 目的 探讨Bmi1蛋白在前列腺癌中的表达及临床意义。方法 应用免疫组织化学方法对前列腺癌(65例)和良性前列腺增生(15例)标本中Bmi1蛋白表达进行检测,将Bmi1染色结果与临床病理参数进行对照研究。结果 Bmi1在前列腺癌组织中的表达较良性增生组织明显增加(P <0.01);Bmi1的表达与Gleason评分具有相关性(P <0.01),与危险分级(P=0.013)相关,与前列腺癌复发进展相关(P <0.05),但Bmi1表达和前列腺特异性抗原(prostate specific antigen,PSA)浓度之间无明显的相关性。结论 Bmi1蛋白在前列腺癌组织中的表达增加,其表达与肿瘤的低分化、高风险和不良预后明显相关。
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| 关 键 词： | Bmi1 前列腺癌 免疫组织化学 |
| 收稿时间： | 2016-04-06 |
Expression of Bmi1 in prostate cancer and its clinical implication |
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| Lin Yunhua,Jiang Yongguang,Fang Wei,Wang Junsheng,Zhou Shaoyou,Sun Xiumei. Expression of Bmi1 in prostate cancer and its clinical implication[J]. Journal of Capital Medical University, 2016, 37(3): 323-326. DOI: 10.3969/j.issn.1006-7795.2016.03.013 |
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| Authors: | Lin Yunhua Jiang Yongguang Fang Wei Wang Junsheng Zhou Shaoyou Sun Xiumei |
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| Affiliation: | 1. Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;2. Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;3. Class 2, Grade 2011, School of Medicine, Capital Medical University, Beijing 100069, China;4. Class of Seven-year Program, Grade 2011, School of Medicine, Capital Medical University, Beijing 100069, China |
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| Abstract: | Objective To investigate the expression and significance of Bmi1 protein in prostate cancer (PC).Methods We used immunohistochemistry to study the expression of the Bmi1 protein in PC (n=65) and benign prostate hypertrophy (BPH) (n=15) specimens. The Bmi1 staining scores were compared with several clinicopathological parameters.Results Compared with the BPH specimens, the expression of Bmi1 increased in PC epithelium (P <0.01). The expression of Bmi1 was associated with high Gleason scores (P <0.01), pre-treatment risk stratification (P=0.013), and recurrence or progression (P <0.05) of PC patients. There was no statistically significant association between Bmi1 expression and serum prostate specific antigen (PSA) level. Conclusion The expression of Bmi1 was increased in PC specimens and was associated with poor differentiation, high risk and poor prognosis of the cancer. |
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| Keywords: | Bmi1 prostate cancer immunohistochemistry |
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