补肾养肝祛邪方治疗慢性乙型肝炎肝肾阴虚证临床研究

目的:观察补肾养肝祛邪方治疗慢性乙型肝炎肝肾阴虚证患者的临床效果。方法:将符合纳入标准的70例慢性乙型肝炎肝肾阴虚证患者随机分为两组,对照组35例单纯口服恩替卡韦分散片治疗,治疗组35例在对照组治疗基础上加用补肾养肝祛邪方颗粒剂,疗程均为24周,比较两组患者疗效指标差异。结果:治疗组在减轻中西医临床症状体征、恢复肝功能、提高HBe Ag转阴率及HBe Ab阳转率、降低HBV-DNA水平、降低肝脏弹性检测值方面均优于对照组(P0.05);总有效率治疗组91.4%,对照组54.3%,差异具有统计学意义(P0.05)。结论:补肾养肝祛邪方协同治疗慢性乙型肝炎肝肾阴虚证能显著保护患者肝脏功能、改善临床症状及提高临床疗效。

Clinical Study on the Efficacy of Bushen Yanggan Quxie Formula for Patients with Chronic Hepatitis B of Liver and Kidneys Yin Deficiency

Objective:To observe the effects of Bushen Yanggan Quxie formula on patients with chronic hepatitis B of liver and kidneys yin deficiency. Methods:Seventy patients with chronic hepatitis B of liver and kidneys deficiency who met with the inclusion criteria were randomly divided into the control group and treatment group,with 35 patients in each group. In the control group,patients were given oral administration of entecavir dispersible tablets,while in the treatment group,patients were given oral administration of entecavir dispersible tablets and Bushen Yanggan Quxie granules. The treatment lasted for 24 weeks. After the treatment,patients in both groups were compared on difference of clinical effect. Results:The effects in the treatment group were better than that in the control group,including relieving clinical symptoms,improving liver function,increasing the negative rate of HBe Ag and positive rate of HBe Ab,lowering HBV-DNA level,reducing the liver elasticity value(P<0.05). The total effective rate in the treatment group was 91.4%,and in the control group was 54.3% with obvious difference(P<0.05). Conclusion:Bushen Yanggan Quxie formula with entecavir dispersible tablets has a significantly higher efficacy in protecting the liver,relieving clinical symptoms,and increasing the clinical curative effect in patients with chronic hepatitis B of liver and kidneys yin deficiency,than entecavir dispersible tablets alone.