| Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head |
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| 引用本文： | Puwei Yuan,Xijing He,Dong Wang,HaoPeng Li,Binshang Lan,Huiru Lu. Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head[J]. 南京医科大学学报(自然科学版), 2005, 19(3) |
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| 作者姓名： | Puwei Yuan Xijing He Dong Wang HaoPeng Li Binshang Lan Huiru Lu |
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| 作者单位： | Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China |
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| 基金项目： | 山西省中医药管理局资助项目 |
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| 摘 要： | Objective: To explore the effect of tumor necrosis factor-α(TNF-α)on the occurrence of steroid-induced avascular necrosis of femoral head(SANFH). Methods: Twenty-four rabbits were firstly divided into void group ( n = 12) and model group ( n =two groups were killed respectively to observe whether the model was successful. The level of TNF-α in serum of the residual rabbits of the two groups was examined in Radioimmunoassay method. Results: The level of TNF-α in model group is significantly higher than that in void group( P ＜0.001) under the premise of the model of SANFH success by histological observation. Conclusion: The rise of level of TNF-α may be one of the most important factors in the occurrence of SANFH.
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| 关 键 词： | femur head necrosis tumor necrosis factor-α Pathological processes |
Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head |
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| Puwei Yuan,Xijing He,Dong Wang,HaoPeng Li,Binshang Lan,Huiru Lu. Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head[J]. Acta Universitatis Medicinalis Nanjing, 2005, 19(3) |
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| Authors: | Puwei Yuan Xijing He Dong Wang HaoPeng Li Binshang Lan Huiru Lu |
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| Abstract: | Objective: To explore the effect of tumor necrosis factor-α(TNF-α)on the occurrence of steroid-induced avascular necrosis of femoral head(SANFH). Methods: Twenty-four rabbits were firstly divided into void group ( n = 12) and model group ( n =two groups were killed respectively to observe whether the model was successful. The level of TNF-α in serum of the residual rabbits of the two groups was examined in Radioimmunoassay method. Results: The level of TNF-α in model group is significantly higher than that in void group( P ＜0.001) under the premise of the model of SANFH success by histological observation. Conclusion: The rise of level of TNF-α may be one of the most important factors in the occurrence of SANFH. |
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| Keywords: | femur head necrosis tumor necrosis factor-α Pathological processes |
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