粘着斑蛋白、雄激素受体在前列腺癌中的表达及相关性研究

目的:检测粘着斑蛋白(VCL)和雄激素受体(AR)在良性前列腺增生(BPH)和前列腺癌(PCa)中的表达情况,并分析其与PCa不同临床分期、病理分级、PSA水平之间的相互关系。方法:采用免疫组化法检测18例BPH组织,38例PCa组织中VCL、AR的表达。并分析两者在BPH、PCa中的表达差异,在PCa不同临床分期、病理分级、初次PSA检测水平的表达差异,以及两者之间的相关性。结果:VCL在PCa中的表达较BPH组织增多,AR表达在BPH、PCa中无明显差异;VCL、AR在PCa组织中的表达与肿瘤临床分期、病理分级密切相关,与PSA值无明显关系;VCL、AR在PCa组织中的表达存在正相关。结论:VCL在BPH、PCa的表达具有差异性,可以作为前列腺良、恶性疾病鉴别诊断的一个潜在指标;AR、VCL随PCa进展表达逐步下降,两者存在正相关,两者结合可以成为PCa进展的诊断、预后评价指标。

Vinculin and the androgen receptor in prostate cancer:Expressions and correlations

Objective:To investigate the expressions of vinculin(VCL) and the androgen receptor(AR) in benign prostatic hyperplasia(BPH) and prostate cancer(PCa) and analyze their relationship with the clinical stage and pathological grade of PCa and the level of PSA.Methods:We detected the expressions of VCL and AR in 18 cases of BPH and 38 cases of PCa by immunohistochemistry,analyzed the differences of VCL and AR expressions in BPH and PCa in different clinical stages and pathological grades of PCa,compared the primary levels of PSA,and studied their correlations.Results:The positive rate of VCL was significantly higher in PCa than in BPH tissues(P < 0.05),while that of AR showed no significant differences between the two groups(P > 0.05).Both the expressions of VCL and AR were closely related with the clinical stage and pathological grade of PCa(P < 0.05),but not with the PSA level(P> 0.05).There was a positive correlation between the expressions of VCL and AR in PCa tissues(r = 0.489,P< 0.05).Conclusion:VCL is expressed differently in BPH and PCa,which may serve as an indicator for the differential diagnosis of benign and malignant prostate diseases.The expressions of AR and VCL are gradually reduced with the progression of PCa,with a positive correlation between them,and could be used jointly to evaluate the progression and prognosis of PCa.Natl J Androl,2010,16(9):794-798