下肢深静脉血栓患者口服华法林初始剂量探讨 |
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引用本文: | 陈洪碧,蒋岚杉,王雪钢,白斗,武少辉,张效杰.下肢深静脉血栓患者口服华法林初始剂量探讨[J].实用医院临床杂志,2014(5):170-171. |
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作者姓名: | 陈洪碧 蒋岚杉 王雪钢 白斗 武少辉 张效杰 |
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作者单位: | 四川省绵阳市中心医院血管外科,四川绵阳621000 |
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摘 要: | 目的:探讨不同年龄的下肢深静脉血栓( deep venous thrombosis ,DVT)患者口服华法林的最佳初始剂量。方法我科2012年1月至2013年10月收治112例急性下肢深静脉血栓患者,根据患者年龄分为甲、乙、丙三组,并给予不同的初始剂量,甲组27例(<51岁,初始剂量3.75 mg),乙组52例(51~70岁,初始剂量2.5 mg),丙组33例(>70岁,初始剂量1.25 mg)。通过监测国际化标准比值( INR)调整华法林用量,监测三组患者INR达到2.0~3.0时的时间及华法林维持剂量。结果 INR达到2.0~3.0时,甲组用时(7.2±1.2)d,华法林剂量为(4.23±0.82)mg;乙组用时(9.3±1.5)d,华法林剂量为(4.05±0.64)mg;丙组用时(9.7±0.7)d,华法林剂量为(3.32±0.45)mg。结论对于不同年龄的急性DVT患者,可选择不同的华法林初始剂量,使患者更快、更安全的达到维持剂量。
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关 键 词: | 下肢深静脉血栓 华法林 抗凝 |
An investigation of initial doses of oral warfarin in treatment of patients with lower extremity deep vein thrombosis |
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Institution: | CHEN Hong, JIANG Lan-shan, WANG Xue-gang, BAI Dou, WU Shao-hui, ZHANG Xi-ao-jie (Department of vascular surgery, Sichuan Mianyan Central Hospital ,Mianyan 621000, China) |
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Abstract: | Objective To explore the optimal initial doses of oral warfarin in treatment of patients with deep venous thrombosis ( DVT) in different ages .Methods One hundred and twelve patients with acute DVT were received and cured in our department from January 2012 to October 2013.The patients were divided into A ,B and C groups according to the patient's age.The three groups were given different initial dose.The group A (n =27 with age 〈51 years old) was give an initial dose of 3.75 mg.The group B (n =52 with age 51-70 years old) was given an initial dose of 2.5 mg.The group C (n =33 with age〉70 years old) was given an initial dose of 1.25 mg.The warfarin doses were adjusted through monitoring INR .The time of reaching INR 2.0-3.0 and warfarin maintenance do-ses were monitored.Results The time of reaching INR 2.0-3.0 was(7.2 ±1.2)d in the group A,(9.3 ±1.5)d in the group B and (9.7 ±0.7)d in the group C,respectively.The maintenance warfarin doses were (4.23 ±0.82)mg in the group A,(4.05 ±0.64)mg in the group B and (3.32 ±0.45)mg in the group C,respectively.Conclusion For acute DVT patients,an initial dose of warfarin should be selected according to ages of patients so that patients could reach the maintenance doses faster and safer . |
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Keywords: | Deep vein thrombosis Warfarin Anticoagulant |
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