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| 震颤停汤对帕金森病模型小鼠行为学的影响 | |
| 引用本文： | 柴天川,胡晓梅,刘丽芬.震颤停汤对帕金森病模型小鼠行为学的影响[J].陕西中医学院学报,2006,29(1):44-47. |
| 作者姓名： | 柴天川 胡晓梅 刘丽芬 |
| 作者单位： | 1. 河北省中医院,河北,石家庄,050017 2. 成都中医药大学,四川,成都,610075 3. 河北省优抚医院,河北,石家庄,050011 |
| 摘 要： | 目的研究震颤停汤对帕金森病(PD)模型小鼠行为学的影响,初步探讨其治疗PD的机理。方法采用C57BL/6J褐鼠MPTP腹腔注射(ip)复制PD模型,观察震颤停汤对其行为学的影响,并探讨其作用机理。以上实验均与安坦组作对照。结果震颤停汤高剂量(10g生药/kg)、中剂量(5g生药/kg)、低剂量(2.5g生药/kg)能够显著缩短小鼠爬杆时间差值(P<0.01);高剂量能够显著增加小鼠自主活动(P<0.01)并能够增加小鼠悬挂能力评分(P<0.01)。结论震颤停汤能够增加小鼠的自主活动,提高肢体运动协调能力。震颤停汤对PD模型小鼠具有保护作用。 |
| 关 键 词： | 震颤停汤 帕金森病 行为学 |
| 文章编号： | 1002-168X（2006）01-0044-04 |
| 收稿时间： | 2005-09-08 |
| 修稿时间： | 2005年9月8日 |
The Influence of Quiver- killer Soup on Behaviorism of Model Rats Suffered Parkinson's Disease(PD) |
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| Chai Tianchuan,Hu Xiaomei,Liu Lifen.The Influence of Quiver- killer Soup on Behaviorism of Model Rats Suffered Parkinson''''s Disease(PD)[J].Journal of Shaanxi College of Traditional Chinese Medicine,2006,29(1):44-47. | |
| Authors: | Chai Tianchuan Hu Xiaomei Liu Lifen |
| Institution: | 1. Hebei Hospital of TCM, Shijiazhuang, Hebe, 050017 ; 2. Chengdu University of TCM, Chengdu, Sichuan, 610075; 3. Hebei YouFu Hospital, Shijiazhuang, Hebei, 050011 |
| Abstract: | Objective To study the influence of quiver-killer soup to behaviorism of model rats suffered PD and to approach the mechanism of treating PD preliminarily.Methods C57BL/6J to give the rats MPTP intraperitoneal injection(IP)to copy PDmodel,to observe the influence of quiver-killer soup to behaviorism,and to approach the mechanism.The above experiment should be compared with the artane group.Results The quiver-killer soup with the dosage large(unprocessed drug 10g/kg)moderate(5k/kg) and small(2.5k/kg) can notably shorten the time difference of rats to climb pole(P<0.01).Large dosage can notably improve the initiative activities(P<0.01) and the hanging ability(P<0.01)of the rats.Conclution Quiver-killer soup can improve the initiative activities and the limbs coordination of the PD model rats and protect them. |
| Keywords: | quiver-killer soup Parkinson's disease behaviorism |
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