| 棉酚对大鼠血睾屏障影响的研究 |
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| 引用本文： | 杨育州,吴东,王乃英,陈啸梅. 棉酚对大鼠血睾屏障影响的研究[J]. 生殖与避孕, 1982, 0(2) |
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| 作者姓名： | 杨育州 吴东 王乃英 陈啸梅 |
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| 作者单位： | 中国医学科学院基础医学研究所(杨育州，吴东，王乃英)，中国医学科学院基础医学研究所(陈啸梅) |
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| 摘 要： | 本实验采用辣根过氧化物酶、硝酸镧和氯化锂示踪观察成年大鼠灌服棉酚后血睾屏障的变化。成年雄性大鼠连续灌服醋酸棉酚30毫克/公斤/日2周、4周和6周后,血管内分别灌流0.75M 氯化锂溶液、2%硝酸镧溶液和睾丸内注射辣根过氧化物酶。结果表明,大鼠灌服棉酚达抗生育效果时,并未显示血睾屏障通透性损伤。因此,可以排除棉酚作用于支持细胞或血睾屏障继而间接影响生精细胞的可能性。
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STUDIES ON THE EFFECT OF GOSSYPOL ON BLOOD-TESTIS BARRIER IN RATS |
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| Abstract: | Observations of the effects of gossypol on the blood-testis barrier in adult rats have beencarried out by using the tracing techniques—vascular perfusion of 0.75M LithiumChloride,and of 2% Lanthanum Nitrate,and intratesticular injection of Horseradishperoxidase—two,four and six weeks respectively after administration of a daily dose of30mg/kg of gossypol acetate.The experimental results demonstrated clearly that gossypol:everely damaged the sper-matogenic target cells but no impairment of the permeability of the blood-testis barrier wasseen.The possibility was excluded that gossypol damaged the Sertoli cells or interferedwith the function of the blood-testis barrier,thus interrupting spermatogenesis. |
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