| COX-2在卵巢上皮性癌中的表达及临床意义 |
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| 引用本文： | 朱巧英,胡建铭,周欣,康苏娅,詹升华,顾冬梅,虞杰. COX-2在卵巢上皮性癌中的表达及临床意义[J]. 苏州大学学报(自然科学版), 2006, 26(3): 464-466 |
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| 作者姓名： | 朱巧英 胡建铭 周欣 康苏娅 詹升华 顾冬梅 虞杰 |
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| 作者单位： | 苏州大学附属第一医院妇产科,江苏苏州215006 |
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| 摘 要： | 目的 研究卵巢上皮性癌中环氧化酶-2（COX-2）的表达情况。方法采用免疫组化法用COX-2特异性抗体检测57例卵巢上皮性癌、20例卵巢良性上皮性肿瘤和10例正常卵巢组织中COX-2的表达。结果卵巢上皮性癌和卵巢良性上皮性肿瘤组织中有COX-2的免疫着色，而正常卵巢组织中未见一例着色。卵巢上皮性癌中COX-2（61.40％）的阳性表达率明显高于卵巢良性上皮性肿瘤和（25．0％）正常卵巢组织（P〈0．05），COX-2的表达与卵巢上皮性癌的临床分期、病理分级及腹水的多少无关（P〉0．05）。结论COX-2表达上调可能与卵巢上皮性癌的发生有关，COX-2蛋白能为卵巢癌的早期诊断提供依据。
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| 关 键 词： | 卵巢肿瘤 环氧化酶-2 |
| 文章编号： | 1673-0399(2006)03-0464-03 |
| 收稿时间： | 2005-09-10 |
| 修稿时间： | 2005-09-10 |
Cyclooxygenase-2 Expression in Ovarian Epithelial Carcinoma |
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| ZHU Qiao-ying, HU Jian-ming, ZHOU Xin, et al. Cyclooxygenase-2 Expression in Ovarian Epithelial Carcinoma[J]. Suzhou University Journal of Medical Science, 2006, 26(3): 464-466 |
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| Authors: | ZHU Qiao-ying HU Jian-ming ZHOU Xin et al |
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| Affiliation: | Dep of Gynecology and Obstetrics, the First Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215006, China |
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| Abstract: | Objective To investigate the expression of Cyclooxyenase-2(COX-2) in ovarian epithelial carcinoma.Methods The COX-2 protein was detected in 57 samples of ovarian epithelial carcinomas,20 samples of benign ovarian epithelial tumors and 10 normal ovarian issues using COX-2 specific antibody by immunohistochemistry.Results COX-2 immunoreaction was observed in 35/57((61.40%)) cases of ovarian epithelial carcinomas,5/20(25%) cases of benign ovarian epithelial tumors and no case of normal ovarian issues.The percentage of COX-2 positivity was significantly higher in ovarian epithelial carcinoma than that in benign ovarian epithelial tumors and normal ovarian issues(P<(0.05)).The expression of COX-2 did not differ in distribution according to FIGO stage,tumor grade and ascites(P>0.05).Conclusion Uregulation of COX-2 expression may play an important role in the oncogenesis of ovarian epithelial carcinomas.COX-2 protein can be used for early diagnosis. |
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| Keywords: | ovarian neoplasms cyclooxygenase-2(COX-2) |
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