咽异物感伴有咽喉反流患者抗反流治疗的临床观察

目的 观察抗反流治疗对咽异物感伴有咽喉反流的临床疗效。 方法 将门诊以咽异物感自评超过3分,患病1个月以上的患者,进行反流症状指数量表(RSI)及反流临床表现量表(RFS)评分,对RSI超过13分及RFS超过7分的患者进行抗反流治疗,以能持续治疗8周以上为有效观察对象,共104例。分析入组患者反流各症状发生率、反流临床表现各体征发生率,并进行疗效评定。 结果 104例咽异物感患者多有反流症状清嗓动作(92/104,88.46%),主要反流体征为后连合肥厚(97/104,93.27%),红斑/充血(89/104,85.57%),喉内黏稠分泌物(87/104,83.65%),喉室阻塞(73/104,70.19%)等,经抗反流治疗,有效61例,有效率为58.65%;RSI治疗前后比较,差异有统计学意义(t=1.975,P<0.05);RFS治疗前后比较,差异无统计学意义(t=1.258,P>0.05)。 结论 咽异物感伴反流症状的患者,通过反流治疗是有效的。对于有咽异物感的患者,经过长期治疗效果不明显,应考虑是否有咽喉反流的可能。

Clinical observation of anti-reflux treatment in patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux

Objective To observe the clinical efficacy of anti-refleux therapy in patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux.Methods A total of 104 patients were selected as study subjects, who had self-rating foreign-body sensation score >3 points,disease course≥1 months,and received continuous anti-re-flux treatment for more than 8 weeks due to reflux symptom index (RSI)>13 points and reflux clinical presentation syndrome (RFS) >7 points after scoring.The rates of all reflux syndromes and signs of reflux clinical symptoms were analyzed,and clinical efficacy was evaluated.Results Of the 104 patients,most had reflux symptom hawking behav-ior (92 /104,88.46%),with primary reflux signs being posterior commissurehypertrophy (97 /104,93.27%),Erythe-ma/congestion (89 /104,85.57%),intra-throat sticky secretions (87 /104,83.65%),ventriculuslaryngis obstruction (73 /104,70.19%)and so on.After anti-reflux treatment,61 were effective,with effective rate of 58.65%.Com-pared with treatment before,there was significant difference in RSI (t =1.975,P <0.05)but no significant difference was observed in RFS (t=1.258,P>0.05)after treatment.Conclusion Anti-reflux treatment is effective to patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux.As to patients with pharyngealforeign body sensation,laryngopharyngeal reflux should be considered if long-term treatment shows no significant efficacy.