阻塞性睡眠呼吸暂停程度与中性粒细胞／淋巴细胞比值的相关性研究

目的：探讨研究中性粒细胞／淋巴细胞比值（NLR）与阻塞性睡眠呼吸暂停综合征（OSAS）程度的关系。方法将158例按照睡眠期呼吸暂停低通气指数（AHI）情况分为4个组，分别为正常对照组（n ＝39）、轻度 OSAS组（n ＝38）、中度 OSAS 组（n ＝41）和重度 OSAS 组（n ＝40），此外对重度 OSAS 组中的31例实施持续气道正压（CPAP）治疗3个月，对该31例进行 CPAP 治疗前后对比。比较的血细胞参数包括白细胞、中性粒细胞、淋巴细胞、中性粒细胞／淋巴细胞比值（NLR）。结果NLR 的组间比较显示重度 OSAS 组（3．29±1．19）显著高于正常对照组（1．71±0．69）、轻度 OSAS 组（1．70±0．71），中度 OSAS 组较正常对照组和轻度 OSAS 组亦明显增高（均为P ＜0．05），而正常对照组与轻度 OSAS 组间及中度 OSAS 组与重度 OSAS 组间差异无统计学意义（P ＞0．05）。重度 OSAS 患者 CPAP 治疗前后对比结果显示治疗后 NLR（1．98±0．81）较治疗前 NLR（3．28±0．62）显著降低（P ＜0．05）。此外4个组中 NLR 与睡眠期 AHI 是呈正相关的（r ＝0．758，P ＝0．034），同时最低氧饱和度与 AHI呈负相关（r ＝－0．179，P ＝0．012）。结论NLR 可随着 OSAS 程度的加重而增高，因而可能作为一新的指标用来辅助评估 OSAS 患者体内炎症反应的严重程度。

Correlation between neutrophil/lymphocyte ratio and severity of obstructive sleep apnea syndrome

Objective To investigate the relationship between the neutrophil /lymphocyte ratio (NLR)and severity of obstructive sleep apnea syndrome (OSAS).Methods A total of 158 subjects were recruited and divided into 4 groups based on their apnea hypopnea index (AHI)during sleep:control group (n =39),mild OSAS group (n =38),mod-erate OSAS group (n =41)and severe OSAS group (n =40).In addition,31 patients in the severe OSAS group un-derwent 3-month continuous positive airway pressure (CPAP)treatment.White blood cells,neutrophils,lymphocytes and NLR were compared among groups as well as before and after CPAP treatment.Results The NLR in the severe OSAS group (3.29 ±1.19)was significantly higher than that in the normal control group (1.71 ±0.69),mild OSAS group (1.70 ±0.71);the NLR in the moderate OSAS group was significantly higher than that in the normal control group and mild OSAS group (all P <0.05);there was no significant difference in NLR between the normal control group and mild OSAS group as well as between the moderate OSAS group and severe OSAS group (all P >0.05). Comparison before and after CPAP treatment showed that NLR was significantly lowered after CPAP treatment (P <0.05).There was a positive correlation between AHI and NLR (r =0.758,P =0.034),and a negative correlation between AHI and minimal oxygen saturation (r =-0.179,P =0.012).Conclusion NLR may elevate as OSAS becomes more severe and therefore it may serve as a new auxiliary parameter to evaluate the severity of inflammatory status in OSAS patients.