| 白芷和藁本药对提取工艺研究 |
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| 引用本文： | 王娟,马春梅,袁绍莉,王丹. 白芷和藁本药对提取工艺研究[J]. 药学研究, 2016, 35(11): 632-634. DOI: 10.13506/j.cnki.jpr.2016.11.003 |
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| 作者姓名： | 王娟 马春梅 袁绍莉 王丹 |
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| 作者单位： | 1. 徐州生物工程职业技术学院，江苏 徐州 221006; 徐州市生物制药研发工程中心，江苏 徐州 221006;2. 徐州生物工程职业技术学院,江苏 徐州,221006 |
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| 基金项目： | 徐州生物工程职业技术学院科技计划项目(2015KY01) |
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| 摘 要： | 目的：优选白芷-藁本药对的最佳提取工艺。方法采用正交试验法，以白芷-藁本药对中欧前胡素含量和醇提浸膏得率为指标。采用高液相色谱法测定欧前胡素含量。考察加醇量、醇浓度、提取时间和提取次数对醇提取工艺的影响。结果最佳提取工艺为用80％的乙醇8倍量浸泡1 h 后，回流提取3次，每次提取90 min。结论优选的提取工艺简便、稳定、可行，适合于制剂的生产。
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| 关 键 词： | 白芷-藁本药对 正交试验 提取工艺 欧前胡素 |
Extraction process of the combination of Angelica dahurica and Ligusticum sinense Oliv |
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| WANG Jun,MA Chunmei,YUAN Shaoli and WANG Dan. Extraction process of the combination of Angelica dahurica and Ligusticum sinense Oliv[J]. Journal of Pharmaceutical Research, 2016, 35(11): 632-634. DOI: 10.13506/j.cnki.jpr.2016.11.003 |
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| Authors: | WANG Jun MA Chunmei YUAN Shaoli WANG Dan |
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| Affiliation: | 1.Xuzhou Vocational College of Bioengineering,Xuzhou 221006,China;2.Xuzhou Biological Pharmaceutical Research and Development Engineering Center, Xuzhou 221006,China,1.Xuzhou Vocational College of Bioengineering,Xuzhou 221006,China;2.Xuzhou Biological Pharmaceutical Research and Development Engineering Center, Xuzhou 221006,China,1.Xuzhou Vocational College of Bioengineering,Xuzhou 221006,China;2.Xuzhou Biological Pharmaceutical Research and Development Engineering Center, Xuzhou 221006,China and 1.Xuzhou Vocational College of Bioengineering,Xuzhou 221006,China;2.Xuzhou Biological Pharmaceutical Research and Development Engineering Center, Xuzhou 221006,China |
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| Abstract: | Objective To optimize the extraction process of the combination of Angelica dahurica and Ligusticum sinense Oliv.Methods The preparation process was investigated by L9(34 )orthogonal design with content of imperatorin and the rate of extractum as indexes,using the determination of the content of imperatorin by HPLC.The main factors influ-encing the extraction efficiency such as the amount of added ethanol,ethanol concentration,the time of extraction and times of extraction were investigated.Results The optimum technical condition was as follows:8 times amount of 80% ethanol of soaking 1 hours,extract 3 times and 90 minutes for each time.Conclusion The optimized extraction process was simple, stable and feasible,it can be used in the preparation. |
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| Keywords: | Combination of Angelica dahurica and Ligusticum sinense Oliv Orthogonal test Extraction process Impera-torin |
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