线栓法致大鼠MCAO/IR模型缺血/再灌时间与发病机制研究进展

目的：建立盐酸莫西沙星氯化钠注射液有关物质检查的方法。方法采用苯基柱（4.6 mm ×150 mm，5μm），流动相为乙腈-盐溶液（30：70），检测波长为293 nm，流速为1.30 mL·min-1，柱温为30℃。结果莫西沙星与各已知杂质及降解产物均分离良好，系统适用性良好，杂质A、B、C、D、E线性良好。杂质B、杂质E校正因子分别为1.42、3.40。结论本方法检查盐酸莫西沙星氯化钠注射液有关物质专属性强、灵敏度高、准确可靠、重现性好。

Research progress on the mechanism and IR time in MCAO/IR model rats with string-fastenting method

Objective To establish a method for the inspection of related substances in Moxifloxacin Hydrochloride and Sodium Chloride Injection.Methods The determination was carried on a phenysilyl column(4.6 mm×150 mm,5μm) with acetonitrile-saline solution( 30:70)as mobile phase. The detection wavelength was 293 nm. The flow rate was 1. 3 mL·min-1,and the column temperature was 30℃.Results The developed method could be used for the determination of moxifloxacin,known impurities and its degradation products with a good resolution,the system suitability was fine.The impu-rities(A,B,C,D,E)had good linearity.The corresponding correction factor:impurities B=1.42,impurities E=3.40.Conclu-sion The method can be special,sensitive and accurate with good reproducibility for the inspection of related substances in Moxifloxacin Hydrochloride and Sodium Chloride Injection.