胃食管反流病与喉癌关系的Meta分析

目的 用Meta分析方法评价胃食管反流病与喉癌之间的关系。 方法 计算机检索Pubmed、Embase、Web of Knowledge、CBM和CNKI数据库,文献检索起至时间从建库到2015年5月止,收集公开发表的所有关于胃食管反流病与喉癌关系的病例对照研究,按纳入和排除标准筛选文献并评价纳入研究质量,应用RevMan 5.3和Stata13.1软件进行Meta分析,根据异质性检验结果选择模型并合并效应量OR值,并评价发表偏倚和敏感性分析。 结果 共纳入13个病例对照研究,Meta分析结果显示,喉癌组胃食管反流病的阳性率显著高于对照组［OR=2.68, 95%CI(1.94,3.70),P<0.000 01］。 结论 胃食管反流病可能是喉癌发生的一种危险因素。但是,考虑到研究间的异质性,还需设计更好的研究来进一步证明本Meta分析结论。

Relationship between gastroesophageal reflux disease and laryngeal carcinoma:a meta-analysis

Objective To evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma with meta-analyses.Methods The published studies of the relationship between gastroesophageal reflux disease and la-ryngeal carcinoma were searched in the Pubmed、Embase、Web of Knowledge、CBM and CNKI databases(from the date of establishment of the databases to May 2015).The trails selection based on inclusion and exclusion criteria,the quali-ty of the included studies was assessed and meta-analysis was performed with RevMan 5.3 and Stata 13.1 software.The OR value of included studies were calculated after heterogeneity test and publication bias was assessed by Harbord meth-od.Results A total of 13 studies were recruited.The Meta-analysis showed the positive rate of gastroesophageal reflux disease was significantly higher in the laryngeal carcinoma group compared with the control group [OR =2.68,95%CI (1.94,3.70),P <0.000 01].Conclusion Gastroesophageal reflux disease may be a significant risk factor for laryn-geal carcinoma. However,given the heterogeneity of the published studies,future well-designed studies are needed.