| 固体脂质纳米粒和纳米结构脂质载体在药物传递中的研究进展 |
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| 引用本文： | 宋春晓,何书莲,曹春凤,张国锋,张文君,王嵩,王立. 固体脂质纳米粒和纳米结构脂质载体在药物传递中的研究进展[J]. 药学研究, 2016, 35(4): 234-236,245. DOI: 10.13506/j.cnki.jpr.2016.04.013 |
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| 作者姓名： | 宋春晓 何书莲 曹春凤 张国锋 张文君 王嵩 王立 |
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| 作者单位： | 1. 哈尔滨商业大学药学院,黑龙江 哈尔滨,150076;2. 哈尔滨一洲制药有限公司,黑龙江 哈尔滨,150066;3. 哈尔滨商业大学药学院，黑龙江 哈尔滨 150076; 黑龙江生物科技职业学院，黑龙江 哈尔滨 150025 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目(12541198) |
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| 摘 要： | 基于固体脂质的纳米粒（Solid lipid - based nanoparticles，SLBNs）作为新型药物传递系统比常规的药物传递系统存在优势。通常，基于固体脂质的纳米粒可以分成两种形态，即固体脂质纳米粒（ Solid lipid nanoparticles， SLNs）和纳米结构脂质载体（Nanostructured lipid carriers，NLCs）。但固体脂质纳米粒与纳米结构脂质载体在基质的组成上不同，本文就基于固体脂质的纳米粒的制备技术、表征方法及应用的最新研究进展进行总结，为基于固体脂质的纳米粒进一步研究提供参考依据。
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| 关 键 词： | 基于固体脂质的纳米粒 固体脂质纳米粒 纳米结构脂质载体 药物传递系统 |
Research progress on drug delivery of solid lipid nanoparticles and nanostructured lipid carriers |
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| SONG Chuanxiao,HE Shulian,CAO Chunfeng,ZHANG Guofeng,ZHANG Wenjun,WANG Song and WANG Li. Research progress on drug delivery of solid lipid nanoparticles and nanostructured lipid carriers[J]. Journal of Pharmaceutical Research, 2016, 35(4): 234-236,245. DOI: 10.13506/j.cnki.jpr.2016.04.013 |
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| Authors: | SONG Chuanxiao HE Shulian CAO Chunfeng ZHANG Guofeng ZHANG Wenjun WANG Song WANG Li |
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| Affiliation: | 1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China,2.Harbin YatChau Pharmaceutical Products Co.,Ltd.,Harbin 150066,China,2.Harbin YatChau Pharmaceutical Products Co.,Ltd.,Harbin 150066,China,1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;3.Heilongjiang Vocational College of Biology Science and Technology,Harbin 150025,China,1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China,1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China and 1.School of Pharmacy,Harbin University of Commerce,Harbin 150076,China |
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| Abstract: | Solid lipid - based nanoparticles(SLBNs)were developed as potential alternatives to other conventionaldrug delivery systems. In general,SLBNs are divided into two types:solid lipid nanoparticles(SLNs)and nanostructured lipid carriers(NLCs). SLNs are distinguishable from NLCs by the composition of solid particle matrix. This review provided an o-verview of the preparation and characterization technologies for SLBNs and using focuses on recent advances in drug delivery using SLBNs,providing the reference of SLNBs for further study. |
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| Keywords: | SLBNs SLNs NLCs Drug delivery systems |
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