Do patients with non-ulcer dyspepsia respond differently to Melicobacter pylorieradication treatments from those with peptic ulcer disease? A systematic review |
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作者姓名: | Huang JQ Zheng GF Hunt RH Wong WM Lam SK Karlberg J Wong BC |
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作者单位: | Department of Gastroenterology McMaster University Medical Centre Hamilton Ontario Canada,Department of Medicine Faculty of Medicine University of Hong Kong Hong Kong China,Clinical Trials Center Faculty of Medicine University of Hong Kong Hong Kong China |
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摘 要: | AIM: It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori (H pylori) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for any difference in H pylorieradication rates between PUD and NUD patients. METHODS: A literature search for full articles and meeting abstracts to July 2004 was conducted. We included studies evaluating the efficacy of a proton pump inhibitor (P) or ranitidine bismuth citrate (RBC) plus two antibiotics of clarithromycin (C), amoxicillin (A), metronidazole (M), or P-based quadruple therapies for eradicating the infection. RESULTS: Twenty-two studies met the criteria. No significant difference in eradication rates was found between PUD and NUD patients when treated with 7-d RBCCA, 10-d PCA or P-based quadruple therapies. When the 7-d PCA was used, the pooled H pylori eradication rate was 82.1% (431/525) and 72.6% (448/617) for PUD and NUD patients, respectively, yielding a RR of 1.15 (95%CI 1.01-1.29). However, the statistically significant difference was seen only in meeting abstracts, but not in full publications. CONCLUSION: There is no convincing evidence to suggest that NUD patients respond to H pylori eradication treatments differently from those with PUD, although a trend exists with the 7-d PCA therapy.
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关 键 词: | 非溃疡性消化不良 幽门螺杆菌 消化系溃疡疾病 病理机制 治疗方法 |
收稿时间: | 2004 Sep 24 |
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