| 小窝及小窝蛋白1在肝再生中的作用 |
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| 引用本文： | 李晓晴,杨仙珊,张晶. 小窝及小窝蛋白1在肝再生中的作用[J]. 医学综述, 2009, 15(19): 2915-2917 |
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| 作者姓名： | 李晓晴 杨仙珊 张晶 |
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| 作者单位： | 首都医科大学附属北京佑安医院人工肝中心,北京,100069 |
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| 摘 要： | 生长因子和细胞因子在肝再生过程中发挥着重要作用,小窝蛋白1就是其中之一。小窝蛋白1参与脂质代谢调节、信号转导和物质运输等。小窝蛋白1表达缺陷的小鼠部分肝切除术后肝脏再生能力和存活率降低。小窝蛋白1调节的脂质聚集能促进肝细胞再生过程,在肝细胞损伤后肝细胞的增殖反应机制中发挥着重要作用。
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| 关 键 词： | 小窝 小窝蛋白1 肝再生 |
Caveolin and Caveolin-1 in Liver Regeneration |
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| LI Xiao-qing,YANG Xian-shan,ZHANG Jing. Caveolin and Caveolin-1 in Liver Regeneration[J]. Medical Recapitulate, 2009, 15(19): 2915-2917 |
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| Authors: | LI Xiao-qing YANG Xian-shan ZHANG Jing |
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| Affiliation: | LI Xiao-qing, YANG Xian-shan, ZHANG Jing. ( Artificial Liver Center, Capital Medical University, Beijing Youan Hospital, Beijing 100069, China) |
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| Abstract: | Growth factors and cytokines,including caveolin-1,play important roles in the process of liver regeneration.Caveolin-1 involves in the lipid metabolism,signal conduction and material transportation.Caveolin-1-/-mouse exhibited impaired liver regeneration and low survival rate after a partial hepatectomy.The lipid accumulation mediated by caveolin-1 can promote the process of liver regeneration.Caveolin-1 plays a crucial role in the proliferative response occurring in the liver after cellular damage. |
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| Keywords: | Caveolae Caveolin-1 Liver regeneration |
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