急性毛细支气管炎患儿血浆脂类炎性介质的变化

对３５例急性期和１５例恢复期毛细支气管炎（简称毛支）患儿用放射免疫法测定了血浆白细胞三烯Ｃ＿４（ＬＴＣ＿４）、血栓素Ｂ＿２（ＴＸＢ＿２）、６－酮－前列腺素Ｆ＿（１ａ）（６－Ｋｅｔｏ－ＰＧＦ＿（１ａ））浓度。结果表明：（１）急性期ＬＴＣ＿４明显增高，恢复期降至正常。（２）急性期和恢复期ＴＸＢ＿２、ＴＸＢ＿２／６－Ｋｅｔｏ－ＰＧＦ＿（１ａ）比值均显著增高；６－Ｋｅｔｏ－ＰＧＦ＿（１ａ）急性期明显降低，恢复期升至正常。提示毛支患儿存在ＴＸＡ＿２－ＰＧＩ＿２平衡失调，ＬＴＣ＿４、ＴＸＢ＿２在气道痉挛、阻塞中起了重要作用。同时对３５例急性期测血液ＩｇＥ，结果２０例增高，提示毛支患儿多数存在过敏素质和气道高反应性。

THE CHANGES OF PLASMA LIPID MEDIA- TORS IN BRONCHIOLITIS OF INFANTS

lasma leukotriene C_4 (LTC_4) , thromboxane B2(TXB2) and 6-keto-prostaglandin Fla ( 6-keto-PGFla)were detected in 35 infants at the acute stage of bronchi-olitis and 15 patients at their convalescence stage byusing radioimmunoassay.The concentration of plasma LTC. level at acutestage of bronchiolitis was significantly higher than thatin norrnal subjects and it declined to the normal rangewith clinical improvement. At acute stage, the concen-tration of plasma 6-keto-PGFla decreased, but the con-centration of TXB2 and TXB2/6-keto-PGFla ratio in-creased. At convalescence stage, 6-keto-PGFla andTXB2 became normal, TXB2/6-keto-PGFla ratiodecreased, but still higher than that in control group.The study suggests that imbalance of TXA2 and PGI2exists in patients with bronchiolitis and LTC4 andTXB2 play an important role in bronchiospasm andbronchiostenosis.