Effects of tetrahydropapaveroline on dopamine and 5-hydroxytryptamine metabolism in rat brain in vivo. |
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| Authors: | P Livrea L Di Reda A Giovine A Bertolino |
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| Affiliation: | Neuropsychiatric Clinic, University of Bari, Bari. |
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| Abstract: | HVA and 5-HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L-dopa-induced HVA increase in the rat brain as well as the PCPA-induced 5-HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L-dopa long-term therapy in parkinsonism. |
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