| 以HPMC为骨架的盐酸丁螺环酮缓释片的制备 |
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| 引用本文： | 陈建海,李宝红,蒋青锋.以HPMC为骨架的盐酸丁螺环酮缓释片的制备[J].中国医药工业杂志,2003,34(9):442-443. |
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| 作者姓名： | 陈建海 李宝红 蒋青锋 |
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| 作者单位： | 第一军医大学南方医院药学部,广东广州,510515 |
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| 基金项目： | 广东省科技攻关项目 (2 0 0 2 C3 0 10 3 ) |
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| 摘 要： | 以HPMC单用或与卡波姆934p合用，制备盐酸丁螺环酮缓释片并进行体外释放度的测定。结果表明本品可持续释药24h，且加入卡波姆比单用HPMC为骨架具有更好的缓释效果。
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| 关 键 词： | 盐酸丁螺环酮 缓释片 制备 释放度 |
| 文章编号： | 1001-8255(2003)09-0442-02 |
| 修稿时间： | 2002年12月16 |
Preparation of Buspirone Hydrochloride Sustained Release Tablets with HPMC as Main Matrix |
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| Authors: | CHEN Jian-Hai LI Bao-Hong JIANG Qing-Feng |
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| Abstract: | Buspirone hydrochloride sustained release tablets were prepared by using HPMC alone or HPMC and Carbopol 934p as matrix. The evaluation of in vitro drug release test showed that the buspirone could sustain release through 24 h in both two kinds of tablets, but dissolution of tablets which prepared with HPMC and Carbopol 934p were better than those with HPMC alone. |
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| Keywords: | buspirone hydrochloride sustained release tablets preparation dissolution |
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