周围型肺腺癌CT 征象与癌细胞核PCNA 表达的关系

目的：研究周围型肺腺癌CT征象与癌细胞核PCNA表达的关系。方法 对32例经病理证实的周围型肺腺癌进行一系列增强前后的薄层CT扫描，采用LSAB免疫组化技术，对肿瘤标本进行细胞核PCNA的阳性率进行测定。结果 癌细胞核的PCNA阳性强度与肿瘤分化程度和CT表现有关。结论 肺腺癌出现深分叶征、棘突征、强化显著时，其恶性度更大。

Relationship between the CT Appearance and PCNA Expression in the Cell Nuclear of Peripheral Lung Adenocarcinomas

Purpose To investigate the relationship between the CT appearance and PCNA expression in the cell nuclearof peripheral lung adenocarcinomas. Methods Serial thin-section CT scans were performed before and after injection of iodinated contrast material on 32cases of pathology proven periperal lung adenocarcinomas. The PCNA expression of tumorspecimen was studied by LSAB immunohistochemical method. Results PCNA expression of lung adenocarcinomas correlated with the degree of differentiation of the tumor cell and the CT appearance of lung cancer. Conclusion It was shownthat lung adenocarcinomas with deep lobulation , speculated protuberance and the marked contrast enhancement were associated with higher degree of malignance.