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Validation of an Acoustic Gastrointestinal Surveillance Biosensor for Postoperative Ileus |
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| Authors: | Brennan M. R. Spiegel Marc Kaneshiro Marcia M. Russell Anne Lin Anish Patel Vartan C. Tashjian Vincent Zegarski Digvijay Singh Samuel E. Cohen Mark W. Reid Cynthia B. Whitman Jennifer Talley Bibiana M. Martinez William Kaiser |
| Affiliation: | 2. Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, USA 5. Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, USA 6. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA 7. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, USA 8. UCLA/VA Center for Outcomes Research and Education (CORE), Los Angeles, USA 9. Division of Gastroenterology, West Los Angeles VA Medical Center, Los Angeles, USA 1. Department of Surgery, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA 4. Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, USA 3. UCLA Wireless Health Institute, Henry Samueli School of Engineering and Applied Science, Los Angeles, USA 10. Electrical Engineering Department, University of California, Los Angles, Los Angeles, USA |
| Abstract: | BackgroundPostoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.Study DesignAGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.ResultsThere were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p?p?=?0.017).ConclusionNon-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions. |
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