A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients |
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| Authors: | Manenti Giacomo Galbiati Federica Pettinicchio Angela Spinola Monica Piconese Silvia Leoni Vera Piera Conti Barbara Ravagnani Fernando Incarbone Matteo Pastorino Ugo Dragani Tommaso A |
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| Affiliation: | Department of Experimental Oncology and Laboratories and 1 Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy and 2 Department of Thoracic Surgery, Istituto Clinico Humanitas (ICH), Rozzano, Italy |
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| Abstract: | Mouse Lrmp and Casc1 genes are candidates for the pulmonaryadenoma susceptibility 1 (Pas1) locus, the major determinantof strain variation in lung tumor susceptibility. These genescontain coding and non-coding single nucleotide polymorphisms(SNPs) strongly associated with lung tumor risk in mice. Analysisof LRMP and CASC1 gene SNPs in 361 lung adenocarcinoma (ADCA)patients and 327 healthy controls revealed common SNPs in LRMP(V141L and S197C) and CASC1 (R33S and three intronic variations),and none showed a significant association with lung ADCA risk.However, in the time-dependent Cox regression model, after adjustmentfor age, gender, smoking history and clinical stage, the carrierstatus of the Leu variation (V141L) of the LRMP gene was associatedwith higher mortality in patients with age at tumor onset |
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