Increased in vitro platelet aggregation in hypertriglyceridemias |
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| Authors: | H Riess W Merk C Falkner E Hiller |
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| Affiliation: | 1. School of Pharmacy, Nantong University, Nantong 226019, China;2. School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China;3. Digestive Diseases Center, the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 510001, China;4. Center for Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, 510001 Guangzhou, China;5. Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China;6. School of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250200, China |
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| Abstract: | Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by both turbidometric and impedance technique and also in whole blood (WB) by the impedance method. Whereas platelet aggregation testing by turbidometry was limited by the optical density of the plasma samples in hypertriglyceridemia, the aggregation process could easily be registered in PRP and WB using the impedance method. Threshold aggregatory concentrations with both agonists were significantly lower for all three groups of HLP. |
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