| 低分割放疗联合吉非替尼治疗老年非小细胞肺癌疗效观察 |
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| 引用本文： | 李小龙,党亚正,陆婉玲. 低分割放疗联合吉非替尼治疗老年非小细胞肺癌疗效观察[J]. 西部医学, 2013, 25(9): 1312-1315 |
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| 作者姓名： | 李小龙 党亚正 陆婉玲 |
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| 作者单位： | 解放军第323医院放疗中心,陕西西安,710054 |
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| 基金项目： | 陕西省自然科学基金资助项目(项目编号：2012JM4008) |
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| 摘 要： | 目的探讨三维适形低分割放疗联合吉非替尼治疗老年非小细胞肺癌(NSCLC)的疗效及不良反应。方法对27例老年NSCLC患者实施低分割放疗联合吉非替尼治疗,分割方案:2.5Gy/d、5f/w,总剂量:35~55Gy;口服吉非替尼250mg,1次/日。结果 3个月近期有效率(CR+PR)66.7%,1年生存率63.0%;放射性肺炎发生率25.9%,放射性食管炎发生率29.6%,皮疹发生率37.0%,腹泻发生率22.2%。结论三维适形低分割放疗联合吉非替尼治疗安全有效,不良反应未见明显增加。
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| 关 键 词： | 老年非小细胞肺癌 吉非替尼 低分割 |
Clinical efficacy of hypofractionated high-dose radiotherapy combined with gefitinib for the elderly non-small cell lung cancer |
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| LI Xiao-long , DANG Ya-zheng , LU Wan-ling. Clinical efficacy of hypofractionated high-dose radiotherapy combined with gefitinib for the elderly non-small cell lung cancer[J]. , 2013, 25(9): 1312-1315 |
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| Authors: | LI Xiao-long DANG Ya-zheng LU Wan-ling |
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| Affiliation: | (Xi＇ an Cancer Center, PLA 323 Hospital, Xi＇ an 710054) |
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| Abstract: | Objective To investigate the efficacy and toxicity of three-dimensional eonformal radiotherapy com- bined with gefitinib in elderly NSCLC. Methods 27 eases of elderly NSCLC patients were analyzed. Results The effica- cy rate was 66, 7%. 1-year survival rates were 63.0%, The incidence of radiation pneumonitis was 25.9%. The inci- dence of radiation esophagitis was 29.6%. The incidence of rash was 37.0% ,and the incidence of diarrhea was 22.2%. Conclusion The three-dimensional eonformal Hypofraetionated high-dose radiotherapy combined with gefitinib for elderly non-small cell lung cancer is safely and definitely, |
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| Keywords: | Elderly Non-small cell lung cancer Gefitinib Hypofractionated high-dose |
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