准分子激光角膜上皮下磨镶术中应用丝裂霉素C预防Haze的早期临床观察

目的:探讨准分子激光角膜上皮下磨镶术中联合应用丝裂霉素C预防术后上皮下浑浊(Haze)的发生。方法:患者42例(84眼)分为A、B两组,A组右眼进行常规LASEK手术,不用丝裂霉素C;B组左眼常规LASEK手术 0.2g/L丝裂霉素C棉片于激光治疗区12～15s,术后随访6mo。结果:A组出现1级Haze18例,2级或以上Haze5例,Haze发生率55%;B组出现1级Haze7例,2级或以上Haze2例,Haze发生率21%,两组Haze发生率差异有统计学意义(P<0.001)。结论:LASEK手术中联合应用0.2g/L丝裂霉素C可降低Haze的发生率同时减轻Haze的程度,但是其更远期的疗效及副反应有待于进一步的观察。

Clinical observation of the application of mitomycin C in LASEK to prevent Haze

AIM:To discuss the happen of Haze after prevented treatment of LASEK combined with mitomycin C.METHODS:Forty-two cases(84 eyes) were divided into two groups:group A and B.The right eyes of the cases in group A were treated by LASEK only while the left eyes in group B were treated by LASEK and mitomycin C(0.2g/L) for 12-15 seconds.RESULTS:In group A,grade I Haze in 18 eyes,grade II or over grade II Haze in 5 eyes and the originating rate of Haze was 55%;Meanwhile,In group A,grade I Haze in 7 eyes,grade II or over grade II Haze in 2 eyes and the originating rate of Haze was 21%.There was no significantly different on originating rate of Haze between group A and B(P <0.001) .CONCLUSION:The method of treating eyes by LASEK and mitomycin C(0.2g/L) is effective on easing the Haze degree,but further discussion is needed on its curative effect and side effect.