Newer methods of labeling diagnostic agents with Tc-99m |
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Authors: | Ronnie C Mease Carol Lambert |
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Institution: | Department of Diagnostic Radiology, Division of Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD. USA |
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Abstract: | The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of "3 + 1" complexes, the preparation and use of (99mTcCO]3)+ complexes for labeling biomolecules, the preparation of rhenium steroid inclusion complexes, improvements in both hydrazinonicotinamide labeling chemistry and in the preformed 99mTc complex method of labeling biomolecules, and new solid-phase separation techniques that may allow the isolation of high specific-activity radiopharmaceuticals in a clinical setting. |
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