新生儿缺氧缺血性脑病早期高压氧治疗后SOD、MDA的变化

目的　 研究新生儿缺氧缺血性脑病 (HIE)高压氧治疗后超氧化物歧化酶 (SOD)和丙二醛 (MDA)的变化及其临床意义。 方法 　将 5 5例HIE患儿分为窒息组 ( 5 5例 )、严重窒息组 ( 30例 )和轻度窒息组 ( 2 5例 ) ,患儿均于生后 48h内行高压氧治疗 ,并分别于治疗前后检测SOD和MDA。 结果 　高压氧治疗后 ,窒息组SOD、MDA无显著变化 (P >0 0 5 ) ;严重窒息组患儿MDA上升 (P <0 0 5 ) ,SOD下降 (P <0 0 5 ) ;轻度窒息患儿MDA下降 (P <0 0 5 ) ,SOD无显著变化 (P >0 0 5 )。 结论 　生后 48h内 ,严重窒息的HIE患儿高压氧治疗后 ,可促使自由基增加 ;轻度窒息的HIE患儿行高压氧治疗 ,则有抗自由基损伤的作用

Changes of SOD and MDA in newborns with Hypoxic-ischemic encephalopathy treated with hyperbaric oxygenation

Objective To observe the changes and its clinical significance of superoxide dismutase(SOD)and malondialdehyde(MDA)in newborn infants with hypoxic ischemic encephalopathy(HIE)treated with hyperbaric oxygenation.Methods All patients with HIE were treated with hyperbaric oxygenation,the concentration of SOD and MDA were determined in 30 seriously asphyxiated patients with HIE and 25 mildly asphyxiated patients with HIE respectively.Results After treatment,SOD declined( P <0 05) and MDA increased( P <0 05)in seriously asphyxiated group and MDA declined( P <0 05)in mildly asphyxiated group than the values before treatment.Conclusion These results suggested that treatment with hyperbaric oxygenation impelled free radicals to rise in seriously asphyxiated newborns with HIE and made free radicals to reduce in mildly asphyxiated newborns with HIE.