血清和癌组织硒,锌,铜与胃癌关系的研究

对９７例胃癌患者手术前、后血清和癌组织中硒、锌、铜含量进行分析，发现胃患者血清硒、锌含量明显低于对照组，血清钢和铜／锌比值明显高于对照组。血清元素变化与胃癌危险性之间有明显的剂量反应关系。胃癌组织中硒水平和铜／锌比值显著高于同源正常组织，锌显著低于正常组织。手术切除肿瘤后６周，血清硒、锌仍然低于对照组，血清钢可恢复至正常水平。铜／锌比值则随着术后体质的改善逐渐下降。提示血硒下降和铜／锌比值升高可做为胃癌诊断的重要参数。

Study on Relationship between Selenium, Zinc and Copper in Serum and Malignant Tissues and Stomach Cancer

The serum selenium, zinc and copper levels of 97 cases of stomach cancer were measured pre-and postoperatively. And Se, Zn and Cu levels in 36 malignant and normal stomach tissue samples were also determined. The results showed that serum Se and Zn levels of patients with atomach cancer were significantly lower(p<0.01), while serum Cu level and Cu/ Zn ratios were higher than those of the controls. The data were analyzed by using conditional logistic regression modol. The results showed that lower levels of serum Se, Zn and higher level of Cu and higher Cu/Zn ratio were the risk factors for stomach cancer. The serum Se level still dropped after operation, and Cu level was recoveried in 6 weeks after operation, and Cu/Zn ratio getting dropped after operation. In the malignant tissues, the mean Se level was 56% higher (P<0.05) than in the normal ones. The mean Zn level was decreased by-17% (P<0.01), and the mean Cu/Zn ratio was increased markedly by 33% (P< 0. 05 ). It's possible relationship between lower levels serum Se, Zn and stomach cancer, and higher level Cu was seted off tumor. The serum Cu/Zn ratio should be use as deciding patient's condition prognosis of stomach cancer.