| 用细胞转移法研究苯并（a）芘损伤机理 |
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| 引用本文： | 雷志明 薛彬. 用细胞转移法研究苯并（a）芘损伤机理[J]. 中国公共卫生学报, 1995, 14(2): 78-79 |
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| 作者姓名： | 雷志明 薛彬 |
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| 作者单位： | 北京医科大学卫生毒理学教研室 |
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| 摘 要： | ＢＡＬＡ／Ｃ雌性小鼠一次腹腔注射２００ｍｇ／ｋｇ体重的苯并（ａ）芘（Ｂ（ａ）ｐ）．体液免疫功能受到明显的抑制，脾ＩｇＭ—ＰＦＣ和ＩｇＧ－ＰＦＣ抑制率分别为４４％和６４％．如果给Ｂ（ａ）ｐ染毒小鼠输入正常小鼠的Ｔ细胞或Ｂ细胞，可使受Ｂ（ａ）ｐ抑制的小鼠免疫功能恢复到接近对照组的水平．说明Ｂ（ａ）Ｐ可同时作用于Ｔ细胞和Ｂ细胞．
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| 关 键 词： | 免疫抑制；IgM－PFC；IgG－PFC |
Study of Mechanism of Benzo(a)pyrene Injury by Cell Transfer |
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| Lei Zhiming .et al.,. Study of Mechanism of Benzo(a)pyrene Injury by Cell Transfer[J]. , 1995, 14(2): 78-79 |
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| Authors: | Lei Zhiming .et al. |
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| Abstract: | BALB/c female mice were exposed to B(a)P 200mg/kg intraperitoneally. The humoral mediated immunity were significantly suppressed,both spleen LgM-PFC and IgG-PFC were suppressed 44% and 64% respectively.If transfer the T cell and B cells from normol mice to B(a )P exposure mice ,it could be recovered to the level of control for those B(a)P treated mice.The results indicated B(a )P treated could effect on T and B lymphocytes. |
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| Keywords: | Immunosuppression IgM-PFC IgG-PFC Cell transfer |
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