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Attentional networks and cingulum bundle in chronic schizophrenia |
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| Authors: | Nestor Paul G Kubicki Marek Spencer Kevin M Niznikiewicz Margaret McCarley Robert W Shenton Martha E |
| Affiliation: | aDepartment of Psychology, University of Massachusetts, Boston, MA, United States bClinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States cPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
| Abstract: | Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n = 18) also had available magnetic resonance diffusion tensor imaging (DTI) measures of the cingulum bundle (CB) fractional anisotropy and volume. The patients showed a significantly different pattern of ANT performance, characterized primarily by decreased alerting efficiency. In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration. |
| Keywords: | Schizophrenia Attention Cingulum bundle |
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