| P物质和P物质受体在小鼠胚胎发育期脑内的表达 |
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| 引用本文： | 季华,韩曙,郑轶,孙建刚,凌树才.P物质和P物质受体在小鼠胚胎发育期脑内的表达[J].解剖学报,2006,37(5):578-583. |
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| 作者姓名： | 季华 韩曙 郑轶 孙建刚 凌树才 |
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| 作者单位： | 浙江大学医学院人体解剖学教研室,杭州,310031 |
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| 摘 要： | 目的研究小鼠胚脑发育期间P物质（SP）和P物质受体（SPR）的表达。方法分别取孕11、13、15、17和19d的小鼠胚脑和新生鼠脑。采用SP和SPR酶标免疫组织化学染色观察SP和SPR表达的变化。结果SP自小鼠胚胎11d开始出现少量表达，并一直持续到出生后，主要出现在发育过程中的新纹状体等部位；SPR与SP同时出现并持续到出生后，主要出现在发育过程中的延髓中缝等部位。结论SP和SPR在小鼠发育期间的表达提示SP可能参与中枢神经系统神经元形成和成熟调控。
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| 关 键 词： | P物质 P物质受体 神经发育 免疫组织化学 小鼠 |
| 收稿时间： | 02 6 2006 12:00AM |
| 修稿时间： | 2006-02-062006-05-11 |
THE EXPRESSION OF SUBSTANCE P AND SUBSTANCE P RECEPTOR IN THE DEVELOPMENT OF MOUSE BRAIN |
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| JI Hua,HAN Shu,ZHENG Yi,SUN Jian-gang,LING Shu-cai.THE EXPRESSION OF SUBSTANCE P AND SUBSTANCE P RECEPTOR IN THE DEVELOPMENT OF MOUSE BRAIN[J].Acta Anatomica Sinica,2006,37(5):578-583. |
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| Authors: | JI Hua HAN Shu ZHENG Yi SUN Jian-gang LING Shu-cai |
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| Institution: | Department of Anatomy, Medical College, Zhejiang University, Hangzhou 310031, China |
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| Abstract: | Objective To study the expression of substance P(SP) and substance P receptor(SPR) during the development of mice brains. Methods The expression of SP and SPR during the development of mice brains from embryonic day(E) 11 to postnatal day(P) 0 days was analyzed by immunohistochemical method. Results The expression of SP began at E11 and gradually increased until birth. The expression of SPR began at E11 and maintained stable expression until birth. SP mostly expressed at striatum and SPR mostly expressed at medullary raphe.Conclusion The expression of SP and SPR during the embryo brain stage may indicate that SP could be an important factor involved in the early organization and maturation of neuron. |
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| Keywords: | Substance P Substance P receptor Neuron development Immunohistocbemistry Mouse |
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