小鼠可移植性膀胱移行细胞癌株（BTT739）的建立及实验研究

用化学致癌剂ＢＢＮ诱异Ｔ７３９近交系小鼠膀胱肿瘤，于诱癌２６周时，将其中１只雄性小鼠膀胱癌往同种系小鼠皮下移植获成功。於１９９１年５月２５日建立了我国第一株小鼠可移植性膀胱癌模型，经２年多时间，已移植传代５６代次，其生物学和病理学特征已相对稳定，在同系小鼠移植成功率１００％，无自然消退现象，带瘤小鼠平均存活５４天，病理组织学检查证实ＢＴＴ７３９为低分化小鼠膀胱移行细胞癌，经２０种抗癌药物药敏试验结果表明对其中的１６种显示不同程度敏感。

Establishment and Study of a Transplantable Bladder Transitional Cell Carcinoma Model (BTT739) in T739 Inbred Mice

A transplantable mouse bladder carcinoma line (BTT739) was established at the authors' laboratory on May 25, 1991 and successfully transplanted to inbred mice with relatively stable biologic and pathologic features for 56 generastions. It is believed that it was the first established model of this kind in China. Transplantability in T739-strain mice was achieved with a successful rate of 100% and no spontaneous regression. The survival time for mice with bladder carcinoma was 54 days. Histologically, BTT739 is an undifferentiated transitional cell carcinoma, similar to that of human. Therapeutic tests of 20 drugs showed that BTT739 was sensitive in varying degrees to 16 of them. The sensitivity was similar to that seen in chemotherapy of human bladder carcinoma.