庆大霉素与复方倍他米松治疗原发性三叉神经痛的早期疗效对比研究

目的比较庆大霉素与复方倍他米松用于原发性三叉神经痛的治疗效果。方法将40例经卡马西平等药物治疗无效或者难以耐受其不良反应的原发性三叉神经痛患者分为2组,分别用庆大霉素和复方倍他米松进行三叉神经外周支阻滞。疼痛强度评分采用视觉模拟评分法(visual analogue scale,VAS)评定病人的疼痛程度和治疗效果。分别记录治疗前、治疗后1周、2周、3周、4周、5周的每次注射前、治疗结束后1月、2月、3月的疼痛强度评分,并记录治疗期间出现的不良反应。结果庆大霉素组和复方倍他米松组治疗后的VAS评分与治疗前相比均降低,在治疗后的前2周,庆大霉素组的VAS评分高于复方倍他米松组,差异有统计学意义(P<0.01),在随后的治疗期间,两组的VAS评分差异无统计学意义。结论采用庆大霉素以小剂量、分次局部注射方式,进行神经阻滞治疗三叉神经痛,可以避免使用激素引起的不良反应,且具有不良反应小,可多次重复的优点,对于有激素使用禁忌的原发性三叉神经痛患者,应用庆大霉素进行神经阻滞治疗是理想的替代用药选择。

Comparative Studies on Gentamicin and Compound Betamethasone for the Treatment of Primary Trigeminal Neuralgia

Objective To compare the therapeutic effects and adverse events of gentamicin and betamethasone on primary trigeminal neuralgia.Methods Forty patients with primary trigeminal neuralgia were allocated into two groups to receive a peripheral nerve block with lidocaine combined with gentamicin or betamethasone,respectively,once a week for 5 weeks.Their pain intensity were assessed using visual analogue scale(VAS)before treatment and once a week just prior to every treat.We continued to make such assessments ev...