扶正抗白冲剂对微小残留白血病模型小鼠免疫功能及生存期的影响 |
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引用本文: | 许勇钢,麻柔,胡乃平,刘锋,杨经敏,马玲,胡晓梅.扶正抗白冲剂对微小残留白血病模型小鼠免疫功能及生存期的影响[J].中国中西医结合杂志,2001,21(2):123-125. |
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作者姓名: | 许勇钢 麻柔 胡乃平 刘锋 杨经敏 马玲 胡晓梅 |
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作者单位: | 中国中医研究院西苑医院(北京100091) |
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基金项目: | 国家中医药管理局重点资助课题(No.922153);荣获中国中医研究院1998年度科技进步三等奖 |
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摘 要: | 目的:研究扶正抗白冲剂(FZKBG)对实验小鼠免疫功能及生存期的影响,探讨FZKBG治疗微小残留白血病(MRL)的机理。方法:接种L7212细胞1×10^6/只,接种后第3天腹腔注射环磷酰胺250mg/kg,造成MRL模型上鼠,分成模型对照组、模型给药组,另设正常对照组、正常给药组,分别观察各组小鼠淋巴细胞亚群(CD3^+、CD4^、CD8^+)改变,免疫器官病理变化和生存期。结果:与模型组比较,FZKBG能明显提高正常小鼠和MRL模型小鼠CD3^+、CD4^、CD8^+的百分比和绝对值(P<0.05,P<0.01)。且明显延长MRL模型小鼠存活期,延长生命率29.6%-60.4%。结论:FZKBG能明显延长MRL模型小鼠存活期,其机理可能是通过提高MRL模型小鼠的免疫功能,抑制体内白血病细胞而实现的。
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关 键 词: | 扶正抗白冲剂 微小残留白血病 免疫功能 生存期 |
修稿时间: | 2000年2月2日 |
Effect of Fuzheng Kangbai Granule on Immune Function and Survival Time in Minimal Residual Leukemia Model in Mice |
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Authors: | XU Yong gang MA Rou HU Nai ping |
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Abstract: | OBJECTIVE: To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and study its mechanism. METHODS: MRL model mice were established by hypodermic inoculation with L7212 cells following intraperitoneal injection of cytoxan (CTX) 25 mg/kg 3 days later, and divided into the control group and FZKBG group. The changes of T-lymphocyte subsets, including CD3+, CD4+ and CD8+, and the survival time in model mice were observed. RESULTS: Comparing with the control group, FZKBG could obviously increase both the percentage and absolute value of CD3+ and CD4+ lymphocytes and prolong the survival time of model mice, the prolongation rate being 29.6%-60.4%. CONCLUSION: FZKBG could markedly prolong the survival time of MRL mice, its mechanism might be through elevating the immune function and inhibiting the leukemic cells in model mice. |
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Keywords: | Fuzheng Kangbai Granule minimal residual leukemia immune function |
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