Enzyme activated anti-tumour agents—III. hydrolysis of conjugates of p-hydroxyaniline mustard in aqueous solution |
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| Authors: | Paul Workman John A. Double Derry E.V. Wilman |
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| Affiliation: | 1. Department of Experimental Pathology and Cancer Research, University of Leeds. School of Medicine, Leeds, England;2. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London SW3 6JB, England |
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| Abstract: | The rates of hydrolysis of a series of aromatic nitrogen mustards, in aqueous solution at physiological temperature and pH, have been determined. Identical rates were observed when the hydrolysis reaction was followed either by titration of acid released or by estimation of residual alkylating activity using the Epstein reagent. |
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