Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
| |
| Authors: | B. Almeida-Pititto I. T. Silva A. C. Goulart M. I. H. Fonseca M. S. Bittencourt R. D. Santos M. Blaha S. Jones P. P. Toth K. Kulakarni P. A. Lotufo I. M. Bensenor S. R. G. Ferreira the ELSA Research Group |
| |
| Affiliation: | 1.Department of Preventive Medicine,Federal University of Sao Paulo,S?o Paulo,Brazil;2.School of Public Health,University of S?o Paulo,S?o Paulo,Brazil;3.Department of Internal Medicine,University of S?o Paulo,S?o Paulo,Brazil;4.Center for Clinical and Epidemiological Research, Hospital Universitário,University of S?o Paulo,S?o Paulo,Brazil;5.Lipid Clinic Heart Institute (InCor),University of Sao Paulo, Medical School Hospital,S?o Paulo,Brazil;6.Johns Hopkins Ciccarone Center for the Prevention of Heart Disease,Baltimore,USA;7.Department of Preventive Cardiology,CGH Medical Center,Sterling,USA;8.VAP Diagnostics Laboratory,Birmingham,USA |
| |
| Abstract: | BackgroundNeck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Methods807 individuals (35–54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36.5; 37.9 and 39.5 cm; women: 31.4; 32.5 and 34 cm) and traditional and non-traditional risk factors (lipoprotein subfractions by Vertical Auto Profile, adiponectin, leptin, E-selectin) were compared across groups. In linear regression models, associations of NC with non-traditional risk factors were tested for the entire sample and for low-risk group (≤?2 CVRF).ResultsIn both sexes, BMI, waist circumference, systolic and diastolic blood pressure, fasting and 2-h plasma glucose, HOMA-IR, triglycerides, leptin, E-selectin, small dense LDL-cholesterol, IDL-cholesterol, VLDL3-cholesterol and TG/HDL ratio increased significantly, while HDL2-cholesterol and HDL3-cholesterol decreased across NC quartiles. In linear regression models, a direct association [β(95% CI)] of NC with leptin [(0.155 (0.068–0.242); 0.147 (0.075–0.220)], E-selectin [(0.105 (0.032–0.177); 0.073 (0.006 to 0.140)] and small-dense LDL [(1.866 (0.641–3.091); 2.372 (1.391–3.353)] and an inverse association with HDL2-cholesterol [(??0.519 (??0.773 to ??0.266); ??0.815 (??1.115 to 0.515)] adjusted for age were detected for men and women, respectively.ConclusionOur findings indicate that measurement of NC may be useful for an earlier identification of unfavorable atherogenic metabolic profile in middle-aged individuals at lower cardiovascular risk level. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
