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No significant prognostic value of normal precursor B‐cell regeneration in paediatric acute myeloid leukaemia after induction treatment |
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| Authors: | Anne E Bras Marry M van den Heuvel‐Eibrink Alita J van der Sluijs‐Gelling Eva A Coenen Henk Wind C Michel Zwaan Jeroen G te Marvelde Mirjam van der Burg Brenda Gibson Anita W Rijneveld Valérie de Haas Jacques J M van Dongen Vincent H J van der Velden |
| Institution: | 1. Department of Immunology, Erasmus MC, University Medical Centre Rotterdam, , Rotterdam, The Netherlands;2. Department of Paediatric Oncology/Haematology, Erasmus MC, , Rotterdam, The Netherlands;3. Dutch Childhood Oncology Group, , The Hague, The Netherlands;4. Royal Hospital for Sick Children, , Glasgow, UK;5. Department of Haematology, Erasmus MC, University Medical Centre Rotterdam, , Rotterdam, The Netherlands |
| Abstract: | B‐cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base‐line levels of BCP in children. |
| Keywords: | paediatric AML B‐cells MRD relapse |