MicroRNAs in myeloid malignancies |
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| Authors: | John E. J. Rasko |
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| Affiliation: | 1. Gene & Stem Cell Therapy Program, Centenary Institute, Royal Prince Alfred Hospital, , Camperdown, NSW, Australia;2. Cell and Molecular Therapies, Royal Prince Alfred Hospital, , Camperdown, NSW, Australia;3. Sydney Medical School, University of Sydney, , Camperdown, NSW, Australia |
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| Abstract: | MicroRNAs (miRNAs) are key to the pathogenesis of human malignancies and increasingly recognized as potential biomarkers and therapeutic targets. Haematological malignancies, being the earliest human malignancies linked to aberrant miRNA expression, have consistently underpinned our understanding of the role that miRNAs play in cancer development. Here, we review the expanding roles attributed to miRNAs in the pathogenesis of different types of myeloid malignancies and highlight key findings. |
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| Keywords: | microRNAs leukaemia acute myeloid leukaemia chronic myeloid leukaemia myeloid |
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