Dose‐related cerebellar abnormality in rats with prenatal exposure to X‐irradiation by magnetic resonance imaging volumetric analysis |
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| Authors: | Kazuhiko Sawada Shigeyoshi Saito Miwa Horiuchi‐Hirose Yuki Mori Yoshichika Yoshioka Kenya Murase |
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| Affiliation: | 1. Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, , Tsuchiura, Ibaraki, Japan;2. Department of Medical Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, , Osaka, Japan;3. Department of Nutrition, Faculty of Medical and Health Sciences, Tsukuba International University, , Tsuchiura, Ibaraki, Japan;4. Biofunctional Imaging Laboratory, Immunology Frontier Research Center (WPI‐IFReC), Osaka University, , Osaka, Japan |
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| Abstract: | Cerebellar abnormalities in 4‐week‐old rats with a single whole body X‐irradiation at a dose of 0.5, 1.0, or 1.5 Gy on embryonic day (ED) 15 were examined by magnetic resonance imaging (MRI) volumetry. A 3D T2W‐MRI anatomical sequence with high‐spatial resolution at 11.7‐tesla was acquired from the fixed rat heads. By MRI volumetry, whole cerebellar volumes decreased dose‐dependently. Multiple linear regression analysis revealed that the cortical volume (standardized β = 0.901; P < 0.001) was a major explanatory variable for the whole cerebellar volume, whereas both volumes of the white matter and deep cerebellar nuclei also decreased depending on the X‐irradiation dose. The present MRI volumetric analysis revealed a dose‐related cerebellar cortical hypoplasia by prenatal exposure to X‐irradiation on E15. |
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| Keywords: | cerebellar hypoplasia ionizing irradiation magnetic resonance imaging Purkinje cells voxel‐based morphometry |
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